INTERACTION OF COVALENTLY CLOSED CIRCULAR PM-2 DNA AND HEDAMYCIN

被引：5

作者：

MONG, S ^{[1
]}

STRONG, JE ^{[1
]}

CROOKE, ST ^{[1
]}

机构：

[1] BRISTOL MYERS CO LABS,SYRACUSE,NY 13201

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91721-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of hedamycin with covalently closed circular PM-2 DNA was examined. Hedamycin produced strand breakage detectable in alkaline sucrose gradients. Under neutral conditions hedamycin inhibited ethidium bromide binding and induced conformational changes in PM-2 DNA. © 1979.

引用

页码：237 / 243

页数：7

共 14 条

[1] DNA STRAND SCISSION BY ANTITUMOR PROTEIN NEOCARZINOSTATIN [J].

BEERMAN, TA ;

GOLDBERG, IH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 59 (04) :1254-1261

[2]

BRADNER WT, 1967, ANTIMICROB AGENTS CH, P613

[3] MECHANISM OF DEGRADATION OF DNA BY STREPTONIGRIN [J].

CONE, R ;

HASAN, SK ;

LOWN, JW ;

MORGAN, AR .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1976, 54 (03) :219-223

[4]

ESPERJO RT, 1967, ANAL BIOCH, V72, P95

[5]

HAIDLE CW, 1971, MOL PHARMACOL, V7, P645

[6]

JOEL P B, 1970, Biochimica et Biophysica Acta, V224, P361, DOI 10.1016/0005-2787(70)90569-1

[7]

LEGERSKI RJ, 1977, J BIOL CHEM, V252, P8740

[8]

LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99

[9]

LLOYD RS, 1978, CANCER RES, V38, P3191

[10] STRUCTURE AND SYNTHESIS OF A LIPID-CONTAINING BACTERIOPHAGE .10. IMPROVED TECHNIQUES FOR PURIFICATION OF BACTERIOPHAGE PM2 [J].

SALDITT, M ;

BRAUNSTEIN, SN ;

CAMERINI.RD ;

FRANKLIN, RM .

VIROLOGY, 1972, 48 (01) :259-+

← 1 2 →