RELATIVE EFFICACY OF DRUGS FOR THE TREATMENT OF SLEEPINESS IN NARCOLEPSY

被引:74
作者
MITLER, MM
HAJDUKOVIC, R
机构
[1] Scripps Clinic, Research Foundation, La Jolla, CA 92037
关键词
NARCOLEPSY; METHYLPHENIDATE; AMPHETAMINE; PEMOLINE; CNS STIMULANTS; MULTIPLE SLEEP LATENCY TEST; MAINTENANCE OF WAKEFULNESS TEST;
D O I
10.1093/sleep/14.3.218
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A survey was conducted on 10 polysomnographic studies on the pharmacologic treatment of the sleepiness of narcolepsy. Three studies emplyed the MSLT and 7 employed the MWT as their polygraphic measure of sleep tendency. Statistically and clinically significant therapeutic changes were apparent for pemoline, modafinil, dextroamphetamine and methylphenidate. Codeine, ritanserin and protriptyline did show statistically significant effects. The common feature among the drugs that did produce clinically significant improvements seems to be facilitatory action on central catecholaminergic transmission. Within this group of drugs, only methylphenidate and dextroamphetamine brought MWT sleep latencies to approximately 70% of normal levels.
引用
收藏
页码:218 / 220
页数:3
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