HOMOCHIRAL AMINE SYNTHESIS BY BAKERS-YEAST RESOLUTION OF A BETA-KETO AMIDE - 1-PHENYLETHYLAMINE

被引：12

作者：

HUDLICKY, T

GILLMAN, G

ANDERSEN, C

机构：

[1] Department of Chemistry, Virginia Polytechnic Institute, State University, Blacksburg

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)80207-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Preliminary investigation of the resolution potential of baker's yeast reduction of beta-keto amides has been carried out with 1-phenylethylamine. Enantiomeric excess was determined by direct comparison of resolved enantiomers with derivatives prepared from commercially available (R)-(+)-1-phenylethylamine and was found to be 56-58.6% for the S enantiomer and 76-84.6% for the R enantiomer.

引用

页码：281 / 286

页数：6

共 19 条

[1] ACYLATION EFFECTS ON CHIRAL RECOGNITION OF RACEMIC AMINES AND ALCOHOLS BY NEW POLAR AND NONPOLAR CYCLODEXTRIN DERIVATIVE GAS-CHROMATOGRAPHIC PHASES [J].