EFFECT OF SUBSTANCE-P ON DETRUSOR MUSCLE IN RATS WITH DIABETIC CYSTOPATHY

被引:7
作者
DAHLSTRAND, C
DAHLSTROM, A
AHLMAN, H
JONSSON, O
LUNDSTAM, S
NORLEN, L
PETTERSSON, S
机构
[1] GOTHENBURG UNIV,DEPT UROL,S-41124 GOTHENBURG,SWEDEN
[2] GOTHENBURG UNIV,DEPT NEUROBIOL,S-41124 GOTHENBURG,SWEDEN
来源
BRITISH JOURNAL OF UROLOGY | 1992年 / 70卷 / 04期
关键词
D O I
10.1111/j.1464-410X.1992.tb15794.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Diabetic cystopathy (DCP) is a well known complication in diabetes mellitus (DM). In the present experimental study, DM was induced in rats by streptozotocin and DCP was confirmed on cystometry. In vitro studies on detrusor strips from diabetic rats showed an increased contractile response to substance P (SP) compared with controls, indicating denervation supersensitivity. A decreased response to capsaicin in diabetic detrusor strips indicated a decreased neuronal content of SP or a diminished number of SP-containing sensory nerves. This suggests that DM induces alterations in nerves containing SP which may be at least partly responsible for sensory loss and the development of DCP.
引用
收藏
页码:390 / 394
页数:5
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