DETERMINATION OF RIFAMPICIN AND ISONIAZID IN PHARMACEUTICAL FORMULATIONS BY HPLC

被引：25

作者：

SHAH, Y ^{[1
]}

KHANNA, S ^{[1
]}

JINDAL, KC ^{[1
]}

DIGHE, VS ^{[1
]}

机构：

[1] LUPIN LABS LTD,MIDC,AURANGABAD 431210,MAHARASHTRA,INDIA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 14期

关键词：

D O I：

10.3109/03639049209040861

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A liquid chromatographic procedure for the analysis of Rifampicin (RIF) and Isoniazid (INH) in pharmaceutical dosage forms utilizing reverse phase chromatography was developed. Isolation of analytes was carried out under isocratic conditions with a octadecylsilane column and an aqueous mobile phase containing Methanol (75%) and 0.02 M Disodium Hydrogen Orthophosphate (25%) with pH 4.5 adjusted with orthophosphoric acid. The detection was done at 254 nm. The method is unique in analysing Rifampicin precisely in combination with Isoniazid particularly in liquid formulation. The method is specific and can distinctly isolate the degradation product in suspension.

引用

页码：1589 / 1596

页数：8

共 8 条

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[2]

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