IMPROVED PREPARATION OF L-[METHYL-C-11]METHIONINE BY ONLINE [C-11] METHYLATION

被引：15

作者：

MIZUNO, KI ^{[1
]}

YAMAZAKI, S ^{[1
]}

IWATA, R ^{[1
]}

PASCALI, C ^{[1
]}

IDO, T ^{[1
]}

机构：

[1] TOHOKU UNIV,CYRIC,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 04期

关键词：

D O I：

10.1016/0969-8043(93)90152-Z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

On-line [C-11]methylation using [C-11]methyl iodide has been successfully applied to the preparation Of L-[Methyl-C-11]-methionine (C-11-Met). [C-11]Methyl iodide is first trapped in a short column that contains Porapak Q and L-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [C-11]methylation. The present method can provide practically pure C-11-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

引用

页码：788 / 790

页数：3

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