CARDIOMYOCYTE GROWTH-REGULATION BY CA2+-CALMODULIN

被引:9
作者
GRUVER, CL [1 ]
GEORGE, SE [1 ]
MEANS, AR [1 ]
机构
[1] DUKE UNIV,DEPT PHARMACOL,DURHAM,NC 27710
关键词
D O I
10.1016/1050-1738(92)90029-R
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Elevation of intracellular free Ca2+ concentrations is a common early cellular action of a variety of agents that induce cardiac myocyte hypertrophy. This observation, plus the large body of evidence that implicates Ca2+-calmodulin (CaM) in cell-cycle control in other cells, prompted us to evaluate the role of the CaM signal-transducing pathway in cardiomyocyte growth regulation. Toward that end, several lines of transgenic mice were generated to express elevated levels of CaM in cardiac myocytes during development. Constitutive overexpression of CaM in the hearts of transgenic mice induced both hyperplastic and hypertrophic growth of cardiac myocytes; some characteristics and potential mechanisms of this growth response are the subjects of the present review.
引用
收藏
页码:226 / 231
页数:6
相关论文
共 54 条
  • [1] CELL-CYCLE CONTROL BY CALCIUM AND CALMODULIN IN SACCHAROMYCES-CEREVISIAE
    ANRAKU, Y
    OHYA, Y
    IIDA, H
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1093 (2-3) : 169 - 177
  • [2] 3-DIMENSIONAL STRUCTURE OF CALMODULIN
    BABU, YS
    SACK, JS
    GREENHOUGH, TJ
    BUGG, CE
    MEANS, AR
    COOK, WJ
    [J]. NATURE, 1985, 315 (6014) : 37 - 40
  • [3] MULTIFUNCTIONAL CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE IS NECESSARY FOR NUCLEAR-ENVELOPE BREAKDOWN
    BAITINGER, C
    ALDERTON, J
    POENIE, M
    SCHULMAN, H
    STEINHARDT, RA
    [J]. JOURNAL OF CELL BIOLOGY, 1990, 111 (05) : 1763 - 1773
  • [4] CAMPELL DL, 1990, CALCIUM HEART, P127
  • [5] THE REGULATION OF THE NA+-CA-2+ EXCHANGER OF HEART SARCOLEMMA
    CARONI, P
    CARAFOLI, E
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 132 (03): : 451 - 460
  • [6] CARONI P, 1981, J BIOL CHEM, V256, P3263
  • [7] CALMODULIN AND THE CELL-CYCLE - INVOLVEMENT IN REGULATION OF CELL-CYCLE PROGRESSION
    CHAFOULEAS, JG
    BOLTON, WE
    HIDAKA, H
    BOYD, AE
    MEANS, AR
    [J]. CELL, 1982, 28 (01) : 41 - 50
  • [8] CHANGES IN CALMODULIN AND ITS MESSENGER-RNA ACCOMPANY REENTRY OF QUIESCENT (G0) CELLS INTO THE CELL-CYCLE
    CHAFOULEAS, JG
    LAGACE, L
    BOLTON, WE
    BOYD, AE
    MEANS, AR
    [J]. CELL, 1984, 36 (01) : 73 - 81
  • [9] COOPER RH, 1980, J BIOL CHEM, V255, P1794
  • [10] CROSS F, 1989, ANNU REV CELL BIOL, V5, P341