STICKING COEFFICIENTS OF ADSORBING PROTEINS

被引：25

作者：

WEAVER, DR ^{[1
]}

PITT, WG ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT CHEM ENGN,PROVO,UT 84602

来源：

BIOMATERIALS | 1992年 / 13卷 / 09期

关键词：

PROTEIN ADSORPTION; DIFFUSION; STICKING COEFFICIENTS;

D O I：

10.1016/0142-9612(92)90025-J

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The protein sticking coefficient, phi, the fraction of collisions that result in adsorption, is a function of the molecular interactions between the protein and the surface. A random walk and diffusion-to-capture model was used to describe the kinetics of protein adsorption. The assumption of a constant sticking coefficient leads to a first-order model of the kinetics. A solution of the problem of adsorption from a semi-infinite medium with first-order kinetics at the boundary was obtained by numerical simulation on the computer. The results of the computer simulations match the time dependence observed experimentally. A correlation was developed to estimate phi from experimental data. Phi has been found to be in the range 10(-5)-10(-8) for several protein adsorption kinetic studies reported in the literature.

引用

页码：577 / 584

页数：8

共 24 条

[1]

ALBERTY RA, 1979, PHYSICAL CHEM, P461

[2]

Andrade JD, 1985, SURFACE INTERFACIAL, V2, P1

[3] KINETICS OF ADSORPTION FROM A SOLUTION . ROLE OF DIFFUSION AND OF ADSORPTION-DESORPTION ANTAGONISM [J].