EFFECT OF TRANSFORMING GROWTH-FACTOR-BETA-1 ON PLATELET-DERIVED GROWTH-FACTOR RECEPTOR-BINDING AND GENE-EXPRESSION IN VASCULAR SMOOTH-MUSCLE CELLS FROM SHR AND WKY RATS

被引：10

作者：

AGROTIS, A ^{[1
]}

SALTIS, J ^{[1
]}

BOBIK, A ^{[1
]}

机构：

[1] ALFRED HOSP,ALFRED & BAKER MED UNIT,PRAHRAN,VIC 3181,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1994年 / 21卷 / 02期

关键词：

SPONTANEOUSLY HYPERTENSIVE RAT; TRANSFORMING GROWTH FACTOR-BETA-1; VASCULAR SMOOTH MUSCLE CELL PROLIFERATION;

D O I：

10.1111/j.1440-1681.1994.tb02484.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. This study examined the effects of transforming growth factor-beta 1 (TGF-beta 1) on platelet-derived growth factor-BB (PDGF-BB)-stimulated DNA synthesis, [I-125]-pDGF-BB receptor binding and PDGF-beta receptor mRNA expression in vascular smooth muscle cells (VSMC) isolated from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). 2. TGF-beta 1 inhibited by 40% DNA synthesis stimulated by PDGF-BB in VSMC from WKY rats but potentiated by 20% growth factor-stimulated DNA synthesis in VSMC from the SHR. 3. Since the difference in effect of TGF-beta 1 could not be attributed to differential regulation of [I-125]-PDGF-BB binding activity and PDGF-beta receptor mRNA expression, it is suggested that alterations in intracellular signalling pathways may account for the differential effects of TGF-beta 1 on PDGF-BB-stimulated DNA synthesis in VSMC from SBR and WKY rats.

引用

页码：145 / 148

页数：4

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