PHORBOL ESTER ACTIVATION OF PROTEIN-KINASE-C INHIBITS CNP-STIMULATED CYCLIC-GMP PRODUCTION IN THE MOUSE ATT-20 PITUITARY-TUMOR CELL-LINE

被引:6
作者
GILKES, AF [1 ]
GUILD, SB [1 ]
CRAMB, G [1 ]
机构
[1] UNIV ST ANDREWS,SCH BIOL & MED SCI,MOLEC ENDOCRINOL GRP,ST ANDREWS KY16 9TS,FIFE,SCOTLAND
基金
英国惠康基金;
关键词
D O I
10.1006/bbrc.1994.2607
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Preincubation of AtT-20 mouse pituitary tumour cells with the phorbol ester PMA resulted in a concentration-dependent inhibition of CNP-stimulated cyclic GMP production. The phorbol ester analogue 4 alpha phorbol had no inhibitory effect and 24 h preincubations with PMA resulted in a characteristic down-regulation of the response indicating that the inhibitory actions were mediated via the activation of protein kinase C. Forskolin in the presence of the phosphodiesterase inhibitor IBMX stimulated intracellular cyclic AMP concentrations by up to eight fold, but did not alter basal nor CNP-stimulated cyclic GMP production. These results indicate that CNP-stimulated guanylate cyclase activity associated with the GC-B natriuretic peptide receptor expressed in AtT-20 cells is inhibited by protein kinase C. (C) 1994 Academic Press, Inc.
引用
收藏
页码:1318 / 1324
页数:7
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