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THE EFFECT OF REPEATED ADMINISTRATION OF METHAMPHETAMINE ON DOPAMINE UPTAKE SITES IN RAT STRIATUM

被引：13
作者：
IKAWA, K
WATANABE, A
MOTOHASHI, N
KANENO, S
机构：
[1] TOKYO MED & DENT UNIV,FAC MED,DEPT NEUROPSYCHIAT,BUNKYO KU,TOKYO,TOKYO 113,JAPAN
[2] HIROSHIMA UNIV,SCH MED,DEPT PSYCHIAT & NEUROSCI,MINAMI KU,HIROSHIMA 734,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 167卷 / 1-2期
关键词：
DOPAMINE UPTAKE SITE; H-3] MAZINDOL BINDING; METHAMPHETAMINE; REPEATED ADMINISTRATION; BEHAVIORAL SENSITIZATION;
D O I：
10.1016/0304-3940(94)91022-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this experiment, rats were injected intraperitoneally with 6 mg/kg methamphetamine (MAP) hydrochloride or the same volume of saline once daily for 14 days. Rats were decapitated after a 1-day, 4-day or 10-day withdrawal period. The number and affinity of [H-3]mazindol binding sites in the striatum were measured. Their number in the MAP group decreased as compared with controls after a 1-day withdrawal period, but returned to the control level after a 4-day and 10-day withdrawal period. These results are believed to show that the decrease in dopamine uptake sites after repeated administration of MAP is transient and does not contribute to MAP-induced behavioral sensitization.
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收藏
页码：37 / 40
页数：4
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