Effects of Na+-H+ exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats

被引：31

作者：

Hasegawa, S ^{[1
]}

Nakano, M ^{[1
]}

Taniguchi, Y ^{[1
]}

Imai, S ^{[1
]}

Murata, K ^{[1
]}

Suzuki, T ^{[1
]}

机构：

[1] GUNMA UNIV,SCH MED,COLL MED & TECHNOL,MAEBASHI,GUMMA 371,JAPAN

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1995年 / 9卷 / 06期

关键词：

myocardial infarction; remodeling; amiloride; Na+-H+ exchange blocker; myocyte hypertrophy;

D O I：

10.1007/BF00879877

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effects of amiloride, a Na+-H+ exchange blocker, on ventricular remodeling in an infarcted rat model. In the amiloride group, the left descending coronary artery was ligated and rats were given amiloride (1 mg/kg/day, n = 11) in their drinking water for 4 weeks. In the control group, rats were given water for 4 weeks (n = 8) after myocardial infarction. The rats were killed on day 28. Both the ratio of heart weight to body weight and that of left ventricular weight to body weight were significantly less in the amiloride group (p < 0.05). The diameter of a myocardial fiber in the region adjacent:to the operated area was significantly reduced in the amiloride group compared with the control group (p < 0.05). Left ventricular cavity dimension was significantly smaller in the amiloride group than that in control group (p < 0.05). Our findings suggest that amiloride prevents ventricular remodeling after myocardial infarction.

引用

页码：823 / 826

页数：4

共 20 条

[1] LEFT-VENTRICULAR FAILURE INDUCED BY MYOCARDIAL-INFARCTION .2. TISSUE MORPHOMETRY [J].

ANVERSA, P ;

LOUD, AV ;

LEVICKY, V ;

GUIDERI, G .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (06) :H883-H899

[2] LEFT-VENTRICULAR FAILURE INDUCED BY MYOCARDIAL-INFARCTION .1. MYOCYTE HYPERTROPHY [J].

ANVERSA, P ;

LOUD, AV ;

LEVICKY, V ;

GUIDERI, G .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (06) :H876-H882

[3] AN ANALYSIS OF THE MECHANICAL DISADVANTAGE OF MYOCARDIAL-INFARCTION IN THE CANINE LEFT-VENTRICLE [J].

BOGEN, DK ;

RABINOWITZ, SA ;

NEEDLEMAN, A ;

MCMAHON, TA ;

ABELMANN, WH .

CIRCULATION RESEARCH, 1980, 47 (05) :728-741

[4] PROTECTIVE EFFECTS OF AMILORIDE ON THE ISCHEMIC REPERFUSED RAT-HEART - RELATION TO MITOCHONDRIAL-FUNCTION [J].

DUAN, JM ;

KARMAZYN, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 210 (02) :149-157

[5] LEFT-VENTRICULAR DIASTOLIC PRESSURE-VOLUME RELATIONS IN RATS WITH HEALED MYOCARDIAL-INFARCTION - EFFECTS ON SYSTOLIC FUNCTION [J].

FLETCHER, PJ ;

PFEFFER, JM ;

PFEFFER, MA ;

BRAUNWALD, E .

CIRCULATION RESEARCH, 1981, 49 (03) :618-626

[6]

HARRISON SM, 1992, AM J PHYSIOL, V262, pC348

[7] ACCELERATION OF H+ EXTRUSION VIA NA+-H+ EXCHANGE IN GUINEA-PIG VENTRICULAR PAPILLARY-MUSCLE UNDER INTRACELLULAR ACIDIC CONDITION [J].

HOTOKEBUCHI, N ;

YANO, T ;

TAKESHITA, T ;

NISHI, K .

JAPANESE JOURNAL OF PHYSIOLOGY, 1991, 41 (03) :369-384

[8] AMILORIDE - EFFECTS ON MYOCARDIAL FORCE OF CONTRACTION, SODIUM-PUMP AND NA+/CA-2+ EXCHANGE [J].

KENNEDY, RH ;

BERLIN, JR ;

NG, YC ;

AKERA, T ;

BRODY, TM .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1986, 18 (02) :177-188

[9] LOAD RESPONSIVENESS OF PROTEIN-SYNTHESIS IN ADULT MAMMALIAN MYOCARDIUM - ROLE OF CARDIAC DEFORMATION LINKED TO SODIUM INFLUX [J].

KENT, RL ;

HOOBER, JK ;

COOPER, G .

CIRCULATION RESEARCH, 1989, 64 (01) :74-85

[10] RELATIONS AMONG SODIUM-PUMP INHIBITION, NA-CA AND NA-H EXCHANGE ACTIVITIES, AND CA-H INTERACTION IN CULTURED CHICK HEART-CELLS [J].

KIM, D ;

CRAGOE, EJ ;

SMITH, TW .

CIRCULATION RESEARCH, 1987, 60 (02) :185-193

← 1 2 →