HEPATOCYTE PLASMA-MEMBRANE ECTO-ATPASE (PP120/HA4) IS A SUBSTRATE FOR TYROSINE KINASE-ACTIVITY OF THE INSULIN-RECEPTOR

被引：112

作者：

MARGOLIS, RN

SCHELL, MJ

TAYLOR, SI

HUBBARD, AL

机构：

[1] NIDDK,DIABET BRANCH,BETHESDA,MD

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21205

[3] HOWARD UNIV,DEPT ONCOL,WASHINGTON,DC 20059

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90845-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

pp120 HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a hepatocyte membrane protein called ecto-ATPase. © 1990.

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页码：562 / 566

页数：5

相关论文

共 17 条

[1] TISSUE DISTRIBUTION AND SUBCELLULAR-LOCALIZATION OF AN ENDOGENOUS SUBSTRATE (PP120) FOR THE INSULIN RECEPTOR-ASSOCIATED TYROSINE KINASE [J].

ACCILI, D ;

PERROTTI, N ;

REESJONES, R ;

TAYLOR, SI .

ENDOCRINOLOGY, 1986, 119 (03) :1274-1280

[2] ENDOGENOUS AND EXOGENOUS DOMAIN MARKERS OF THE RAT HEPATOCYTE PLASMA-MEMBRANE [J].

BARTLES, JR ;

BRAITERMAN, LT ;

HUBBARD, AL .

JOURNAL OF CELL BIOLOGY, 1985, 100 (04) :1126-1138

[3]

BARTLES JR, 1985, J BIOL CHEM, V260, P2792

[4] PP-120 - A COMMON ENDOGENOUS SUBSTRATE FOR INSULIN AND IGF-1 RECEPTOR-ASSOCIATED TYROSINE KINASE-ACTIVITY IN THE HIGHLY MALIGNANT AS-30D RAT HEPATOMA-CELLS [J].

FANCIULLI, M ;

PAGGI, MG ;

MANCINI, A ;

DELCARLO, C ;

FLORIDI, A ;

TAYLOR, SI ;

PERROTTI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (01) :168-173

[5]

GIBSON BW, 1988, J BIOL CHEM, V263, P4182

[6] IDENTIFICATION OF RAT HEPATOCYTE PLASMA-MEMBRANE PROTEINS USING MONOCLONAL-ANTIBODIES [J].

HUBBARD, AL ;

BARTLES, JR ;

BRAITERMAN, LT .

JOURNAL OF CELL BIOLOGY, 1985, 100 (04) :1115-1125

[7] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[8]

LIN SH, 1989, J BIOL CHEM, V264, P14408

[9] IDENTIFICATION OF PP120, AN ENDOGENOUS SUBSTRATE FOR THE HEPATOCYTE INSULIN-RECEPTOR TYROSINE KINASE, AS AN INTEGRAL MEMBRANE GLYCOPROTEIN OF THE BILE CANALICULAR DOMAIN [J].

MARGOLIS, RN ;

TAYLOR, SI ;

SEMINARA, D ;

HUBBARD, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7256-7259

[10]

OKLIND C, 1983, J CELL BIOL, V96, P1168