NUCLEOTIDE-SEQUENCE OF THE HEPATITIS-B VIRUS GENOME (SUBTYPE AYW) CLONED IN ESCHERICHIA-COLI

被引：937

作者：

GALIBERT, F ^{[1
]}

MANDART, E ^{[1
]}

FITOUSSI, F ^{[1
]}

TIOLLAIS, P ^{[1
]}

CHARNAY, P ^{[1
]}

机构：

[1] INST PASTEUR,UNITE GENIE GENET,INSERM,U163,F-75015 PARIS,FRANCE

来源：

NATURE | 1979年 / 281卷 / 5733期

关键词：

D O I：

10.1038/281646a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complete nucleotide sequence of hepatitis B virus genome (subtype ayw) cloned in Escherichia coli has been determined using the Maxam and Gilbert method and the dideoxynucleotide method. This sequence is 3,182 nucleotides long. Location of the nonsense codons shows that the coding capacity of the L chain is larger than the coding capacity of the Schain. Eight open regions, able to code for polypeptide chains larger than 100 amino acids, have been located. Region 6, which is the largest, covers more than 80% of the genome. The gene S which codes for polypeptide I of the Hbs Ag and was previously located between coordinates 95.1 and 73.6 is contained in region 7. © 1979 Nature Publishing Group.

引用

页码：646 / 650

页数：5

共 35 条

[1] ISOLATION FROM RAT-LIVER AND SEQUENCE OF A RNA FRAGMENT CONTAINING 32 NUCLEOTIDES FROM POSITION-5 TO POSITION-36 FROM 3' END OF RIBOSOMAL 18S RNA
ALBERTY, H
RABA, M
GROSS, HJ
[J]. NUCLEIC ACIDS RESEARCH, 1978, 5 (02) : 425 - 434
[2] PHOSPHOPROTEINS OF ADENOVIRUS-2
AXELROD, N
[J]. VIROLOGY, 1978, 87 (02) : 366 - 383
[3] BAKER CC, CELL
[4] BERGET SM, 1977, COLD SPRING HARB SYM, V42, P523
[5] ADENOVIRUS-2 MESSENGERS - EXAMPLE OF BAROQUE MOLECULAR ARCHITECTURE
BROKER, TR
CHOW, LT
DUNN, AR
GELINAS, RE
HASSELL, JA
KLESSIG, DF
LEWIS, JB
ROBERTS, RJ
ZAIN, BS
[J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1977, 42 : 531 - 553
[6] EXPRESSION IN ESCHERICHIA-COLI OF HEPATITIS-B VIRUS-DNA SEQUENCES CLONED IN PLASMID-PBR322
BURRELL, CJ
MACKAY, P
GREENAWAY, PJ
HOFSCHNEIDER, PH
MURRAY, K
[J]. NATURE, 1979, 279 (5708) : 43 - 47
[7] LOCALIZATION ON THE VIRAL GENOME AND NUCLEOTIDE-SEQUENCE OF THE GENE CODING FOR THE 2 MAJOR POLYPEPTIDES OF THE HEPATITIS-B SURFACE-ANTIGEN (HBS AG)
CHARNAY, P
MANDART, E
HAMPE, A
FITOUSSI, F
TIOLLAIS, P
GALIBERT, F
[J]. NUCLEIC ACIDS RESEARCH, 1979, 7 (02) : 335 - 346
[8] CLONING IN ESCHERICHIA-COLI AND PHYSICAL STRUCTURE OF HEPATITIS-B VIRION DNA
CHARNAY, P
POURCEL, C
LOUISE, A
FRITSCH, A
TIOLLAIS, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (05) : 2222 - 2226
[9] PRIMARY STRUCTURE OF RABBIT BETA-GLOBIN MESSENGER-RNA AS DETERMINED FROM CLONED DNA
EFSTRATIADIS, A
MANIATIS, T
KAFATOS, FC
[J]. CELL, 1977, 10 (04) : 571 - 585
[10] COMPLETE NUCLEOTIDE-SEQUENCE OF SV40 DNA
FIERS, W
CONTRERAS, R
HAEGEMAN, G
ROGIERS, R
VANDEVOORDE, A
VANHEUVERSWYN, H
VANHERREWEGHE, J
VOLCKAERT, G
YSEBAERT, M
[J]. NATURE, 1978, 273 (5658) : 113 - 120

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