POMC GENE-EXPRESSION IN MOUSE AND HAMSTER MELANOMA-CELLS

被引：48

作者：

SLOMINSKI, A

机构：

[1] Department of Immunology and Microbiology, Albany Medical College, Albany

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

PROOPIOMELANOCORTIN; BETA-ENDORPHIN; MELANOMA;

D O I：

10.1016/0014-5793(91)81274-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, beta-endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.

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页码：165 / 168

页数：4

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