GENDER DIFFERENCE IN RED-BLOOD-CELL THIOPURINE METHYLTRANSFERASE ACTIVITY

被引：32

作者：

KLEMETSDAL, B

WIST, E

AARBAKKE, J

机构：

[1] Department of Pharmacology, University of Tromse, Tromse

[2] Department of Oncology, University of Tromse, Tromse

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1993年 / 53卷 / 07期

关键词：

AZATHIOPRINE; DRUG METABOLISM; 6-MERCAPTOPURINE; SEX DIFFERENCE; TPMT;

D O I：

10.3109/00365519309092580

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

High red blood cell (RBC) thiopurine methyltransferase (TPMT) activity is associated with a higher relapse rate in children with acute lymphoblastic leukaemia on 6-mercaptopurine therapy. RBC TPMT activity is subject to genetic polymorphism and interethnic variation. Higher TPMT activity in male subjects has previously been reported in RBC and liver tissue, but only in non-healthy subjects. In this healthy, drug-free study group the gender difference in the RBC TPMT high activity subgroup was confirmed with 8.3% higher TPMT activity in male subjects (n = 105).

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收藏

页码：747 / 749

页数：3

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