ACTIVE-TRANSPORT OF URIDINE THROUGH A LIQUID ORGANIC MEMBRANE MEDIATED BY PHENYLBORONIC ACID AND DRIVEN BY A FLUORIDE-ION GRADIENT

被引:73
作者
PAUGAM, MF [1 ]
SMITH, BD [1 ]
机构
[1] UNIV NOTRE DAME,DEPT CHEM & BIOCHEM,NOTRE DAME,IN 46556
关键词
ACTIVE TRANSPORT; RIBONUCLEOSIDE; BORONIC ACID; FLUORIDE; LIQUID ORGANIC MEMBRANE;
D O I
10.1016/S0040-4039(00)79210-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Phenylboronic acid simultaneously co-transports the ribonucleoside, uridine, and fluoride ion through an organic liquid membrane. The transport mechanism involves self-assembly of a lipophilic ion-pair comprising of phenylboronic acid, fluoride ion, uridine and tetralkylammonium cation. Active uridine transport (i.e. uphill transport against a concentration gradient) occurs in the direction of a fluoride ion concentration gradient.
引用
收藏
页码:3723 / 3726
页数:4
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