INDIVIDUAL RESIDUE CORRELATION TIMES OF PEPTIDES FROM PROTON RELAXATION PARAMETERS - APPLICATION TO GRAMICIDIN-S

Three 1H nmr relaxation methods are presented for determining the correlation times of interproton vectors in peptides and proteins. Within experimental error a single correlation time, 11 × 10-10 sec., is found for the backbone interproton vectors in gramicidin S. These methods are generally applicable to the measurement of side chain and backbone motional rates of peptides and other biopolymers and can be used for determinations of interproton distances from 1H nuclear Overhauser effects. © 1978.