PHARMACOLOGY OF THE HYPOTHERMIC RESPONSE TO 5-HT1A RECEPTOR ACTIVATION IN HUMANS

被引：92

作者：

LESCH, KP

POTEN, B

SOHNLE, K

SCHULTE, HM

机构：

[1] UNIV WURZBURG,DEPT PSYCHIAT,W-8700 WURZBURG,GERMANY

[2] UNIV KIEL,DEPT MED 1,W-2300 KIEL 1,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 01期

关键词：

Betaxolol; Hypothermia; Ipsapirone; Metergoline; Pindolol; Serotonin receptor (5-HT[!sub]1A[!/sub]);

D O I：

10.1007/BF02657050

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. The response was attenuated by the nonselective 5-HT1/2 receptor antagonist metergoline and was completely antagonized by the nonselective [3-adrenoceptor antagonist pindolol, which interacts stereoselectively with the 5-HT1A receptor. The selective β1-adrenergic antagonist betaxolol had no effect. The findings indicate that IPS-induced hypothermia specifically involves activation of (presynaptic) 5-HT1A receptors. Therefore, the hypothermic response to IPS may provide a convenient in vivo paradigma to assess the function of the presynaptic 5-HT receptor in affective disorders and its involvement in the effects of psychotropic drugs. © 1990 Springer-Verlag.

引用

页码：17 / 19

页数：3

共 12 条

[1] IDENTITY OF INHIBITORY PRESYNAPTIC 5-HYDROXYTRYPTAMINE (5-HT) AUTORECEPTORS IN THE RAT-BRAIN CORTEX WITH 5-HT1B BINDING-SITES [J].