COMPARATIVE METABOLISM AND DNA-BINDING OF 7,12-DIMETHYLBENZ[A]ANTHRACENE AND ITS WEAKLY CARCINOGENIC 5-FLUORO ANALOG

被引：22

作者：

DANIEL, FB

CAZER, FD

DAMBROSIO, SM

HART, RW

KIM, WH

WITIAK, DT

机构：

[1] OHIO STATE UNIV,COLL PHARM,DEPT MED CHEM,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,COLL MED,DEPT RADIOL & PHARMACOL,COLUMBUS,OH 43210

[3] OHIO STATE UNIV,CTR COMPREHENS CANC,COLUMBUS,OH 43210

来源：

CANCER LETTERS | 1979年 / 6卷 / 4-5期

关键词：

D O I：

10.1016/S0304-3835(79)80044-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cultured Syrian hamster embryo cells readily convert both the carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethylbenz[a] anthracene (DMBA), and its weakly carcinogenic analogue, 5-fluoro-7,12-dimethylbenz[a] anthracene (5F-DMBA), to water soluble metabolites. DMBA, however, binds to the hamster cell DNA at least 2.8-3.0 times more extensively than 5F-DMBA. Likewise, 5F-DMBA is converted to water soluble metabolites by liver microsomal preparations at a rate equal to DMBA, but the latter compound binds to DNA 2.6-3.2 times more effectively. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

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页码：263 / 272

页数：10

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