HUMAN SALIVARY PROLINE-RICH (PR) PROTEINS - POSTTRANSLATIONAL DERIVATION OF THE PHENOTYPES

被引：21

作者：

KARN, RC

FRIEDMAN, RD

MERRITT, AD

机构：

[1] NATL LIB MED,LISTER HILL NATL CTR BIOMED COMMUN,BETHESDA,MD 20014

[2] UNIV PENN,SCH DENT MED,DEPT ORAL MED,PHILADELPHIA,PA 19104

来源：

BIOCHEMICAL GENETICS | 1979年 / 17卷 / 11-1期

关键词：

human saliva; isomorphic proteins; posttranslational modifications; proline-rich proteins; proteolytic cleavage;

D O I：

10.1007/BF00504345

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The acidic proline-rich proteins (Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography. Molecular weight determinations, amino acid composition analyses, and polypeptide mapping experiments indicate that the Pr 3 protein is a fragment of the Pr 1 protein. Studies of a parotid saliva factor capable of converting Pr 1 to Pr 3 and Pr 2 to Pr 4 indicate that Pr 3 and Pr 4 are generated from Pr 1 and Pr 2, respectively. Evidence suggests that the converting factor is a protease capable of posttranslationally cleaving Pr 1 and Pr 2, the primary or derived products of alleles Pr1 and Pr2. © 1979 Plenum Publishing Corporation.

引用

页码：1061 / 1077

页数：17

共 33 条

[1] SALIVARY PEROXIDASE (SAPX) - GENETIC MODIFICATION AND RELATIONSHIP TO PROLINE-RICH (PR) AND ACIDIC (PA) PROTEINS [J].