RAI-III AND RAI-VI, CONFORMATIONAL ISOMERS OF ANTITUMOR CYCLIC HEXAPEPTIDES, RA-III AND RA-VI FROM RUBIA-CORDIFOLIA

被引：31

作者：

ITOKAWA, H ^{[1
]}

MORITA, H ^{[1
]}

TAKEYA, K ^{[1
]}

TOMIOKA, N ^{[1
]}

ITAI, A ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 12期

关键词：

D O I：

10.1246/cl.1991.2217

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

RAI-III and VI, conformational isomers of antitumor bicyclic hexapeptides, RA-III and VI, respectively, were isolated from Rubia cordifolia. By the conformational analysis of them using spectroscopic and computational chemical methods, they were shown to have gamma-turn structures at residues 2, 3, and 4, which were stabilized by a hydrogen bond between Ser-2-OH and D-Ala-1-CO.

引用

页码：2217 / 2220

页数：4

共 14 条

[1] BAX A, 1986, J AM CHEM SOC, V108, P2094
[2] ITOKAWA H, 1991, CHEM PHARM BULL, V39, P2161
[3] NEW ANTITUMOR BICYCLIC HEXAPEPTIDES, RA-VI AND RA-VIII FROM RUBIA-CORDIFOLIA - CONFORMATION-ACTIVITY RELATIONSHIP II
ITOKAWA, H
MORITA, H
TAKEYA, K
TOMIOKA, N
ITAI, A
IITAKA, Y
[J]. TETRAHEDRON, 1991, 47 (34) : 7007 - 7020
[4] STUDIES ON ANTITUMOUR CYCLIC HEXAPEPTIDES RA OBTAINED FROM RUBIAE RADIX, RUBIACEAE(IV) - QUANTITATIVE-DETERMINATION OF RA-VII AND RA-V IN COMMERCIAL RUBIAE RADIX AND COLLECTED PLANTS
ITOKAWA, H
TAKEYA, K
MORI, N
KIDOKORO, S
YAMAMOTO, H
[J]. PLANTA MEDICA, 1984, 50 (04) : 313 - 316
[5] ITOKAWA H, 1984, CHEM PHARM BULL, V32, P284
[6] ITOKAWA H, 1986, CHEM PHARM BULL, V34, P3762
[7] ITOKAWA H, 1985, J PHARMACOBIO-DYNAM, V8, pS63
[8] ITOKAWA H, 1991, 38TH ANN M JAP SOC P, P183
[9] ITOKAWA H, 1984, JPN J CANCER RES, V75, P929
[10] GAMMA-TURN AS AN INDEPENDENT CONFORMATIONAL FEATURE IN SOLUTION
KHALED, MA
URRY, DW
OKAMOTO, K
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 72 (01) : 162 - 169

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