SOLVATOCHROMIC ANALYSIS OF THE RETENTION MECHANISM OF 2 NOVEL STATIONARY PHASES USED FOR MEASURING LIPOPHILICITY BY RP-HPLC

被引：36

作者：

VALLAT, P

FAN, W

ELTAYAR, N

CARRUPT, PA

TESTA, B

机构：

[1] Institut de Chimie Thérapeutique, Ecole de Pharmacie Université de Lausanne

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1992年 / 15卷 / 12期

关键词：

D O I：

10.1080/10826079208016330

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipophilicity of a large set of solute was measured by reversed-phase high-performance liquid chromatography using two novel stationary phases, namely an octadecyl polyvinyl-alcohol copolymer (ODP) and an octyl-silane (OS) phase. Solvatochromic analysis of the results showed the ODP/buffer system to bear a close resemblance to 1-octanol/buffer system. In contrast, the OS phase is a stronger H-bond acceptor than 1-octanol and will lead to overestimating the lipophilicity of strong H-bond donor solutes.

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页码：2133 / 2151

页数：19

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