NEUROHYPOPHYSEAL PEPTIDES AS REGULATORS OF GROWTH AND DEVELOPMENT - A REVIEW

被引：18

作者：

CARTER, DA

FAI, CK

MURPHY, D

机构：

[1] Neuropeptide Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 0511

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 1993年 / 4卷 / 01期

关键词：

VASOPRESSIN; OXYTOCIN; MITOGENIC; AUTOCRINE; BRATTLEBORO;

D O I：

10.1007/BF02736686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to their classical hormonal role, the neurohypophyseal peptides vasopressin (AVP) and oxytocin (OT) are also implicated as regulators of growth and development. Mitogenic actions of AVP are particularly well characterized and may underly the potential role of AVP as an autocrine regulator of tumor growth. Effects of AVP and OT on neural development are suggested by numerous studies, but definitive physiological evidence is lacking. Current studies on the molecular characterization of AVP and OT receptors, and on transgenic animals will provide insights into the developmental actions of neurohypophyseal peptides.

引用

页码：11 / 19

页数：9

共 65 条

[1] ONTOGENY OF HYPOTHALAMIC VASOPRESSIN, OXYTOCIN AND SOMATOSTATIN GENE-EXPRESSION [J].