RADIOLYSIS AND RADIOSTERILIZATION OF DRUGS

被引：20

作者：

ZEEGERS, F ^{[1
]}

CRUCQ, AS ^{[1
]}

GIBELLA, M ^{[1
]}

TILQUIN, B ^{[1
]}

机构：

[1] ECOLE PHARM UCI,7230 AV E MOUNIER 72,B-1200 BRUSSELS,BELGIUM

来源：

JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1993年 / 90卷 / 04期

关键词：

D O I：

10.1051/jcp/1993901029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Can the absence of increased toxicological danger in irradiated foods be applied with confidence to drugs ? The World Health Organization stated that up to 10 kGy there is no toxicological hazard. However, even if the irradiated drugs meet official standards, it would have to be established that any traces of radiolysis product formed are not toxic. All the tests from PHARMACOPEIA are not appropriate to detect the radiolysis and new physicochemical tests have to be used. Chromatographic detection of the radiosterilization of antibiotics may be advantageously used when the pharmaceuticals are not radio-resistant. The main obstacle to pratical application is the low sensitivity of the detectors in liquid-liquid chromatography, a re-irradiation of the suspected samples will be necessary after preliminary chromatographic studies.

引用

页码：1029 / 1040

页数：12