SYNTHESIS OF CHAETOMELLIC ACID-A - A POTENT INHIBITOR OF RAS FARNESYL-PROTEIN TRANSFERASE

被引:40
作者
SINGH, SB
机构
[1] Merck Research Laboratories P. O., Rahway, NJ 07065
关键词
D O I
10.1016/0040-4039(93)88094-Y
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Chaetomellic adds are alkyl dicarboxylic acids, isolated from Chaetomella acutiseta and are potent and highly specific farnesyl-pyrophosphate (FPP) mimic inhibitors of Ras farnesyl-protein transferase. The first efficient and biogenetic type total synthesis of chaetomellic acid A has been described herein.
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页码:6521 / 6524
页数:4
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