BETA-ADRENERGIC BLOCKING AGENTS .I. PRONETHALOL AND RELATED N-ALKYL AND N-ARALKYL DERIVATIVES OF 2-AMINO-1-(2-NAPHTHYL)ETHANOL

A series of 76 N-substituted derivatives of 2-amino-1-(2-naphthyl)elhanol (1) has been prepared by a variety of methods. One member of (he series, pronethalol (5), was of some interest clinically as a β-adrenergic blocking agent but was found to cause thymic tumors after prolonged administration to mice. Structure-activity relationships in this series of β-adrenergic blocking agents resemble those previously reported for the isoproterenol series of β-mimetic agents. © 1968, American Chemical Society. All rights reserved.