POLYMORPHONUCLEAR LEUKOCYTE MOTILITY IN VITRO .I. EFFECT OF PH TEMPERATURE ETHYL ALCOHOL AND CAFFEINE USING A MODIFIED BOYDEN CHAMBER TECHNIC

被引：57

作者：

PHELPS, P

STANISLAW, D

机构：

[1] University of Pennsylvania, Philadelphia, Pennsylvania

[2] Rheumatology Research Laboratory, Philadelphia General Hospital, Philadelphia, Pennsylvania

[3] General Clinical Research Center, Philadelphia General Hospital, Philadelphia, 19104, Building 25

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1002/art.1780120304

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A modification of the Boyden chamber technic for studying the motility of human polymorphonuclear leukocytes (PMN's) is presented, and various technical factors which might influence the results are discussed. FMN motility was found to vary considerably over the pH spectrum encountered in healthy and diseased tissue. It is possible that tissue variations in pH, through an effect on FMN motility, may play a regulatory role in the development and resolution of certain types of inflammation. Changes in temperature over a fairly wide range had relatively little effect on PMN motility. Ethyl alcohol and caffeine were found to suppress motility at clinically obtainable concentrations. Copyright © 1969 American College of Rheumatology

引用

页码：181 / +

页数：1

共 26 条

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