IMIPRAMINE AND DESIPRAMINE DECREASE THE GABA-STIMULATED CHLORIDE UPTAKE, AND ANTIGABAERGIC AGENTS ENHANCE THEIR ACTION IN THE FORCED SWIMMING TEST IN RATS

被引：19

作者：

FERNANDEZTERUEL, A

ESCORIHUELA, RM

BOIX, F

LONGONI, B

CORDA, MG

TOBENA, A

机构：

[1] UNIV DUSSELDORF, INST PSYCHOL, INST PHYSIOL PSYCHOL, W-4000 DUSSELDORF 1, GERMANY

[2] UNIV CAGLIARI, CHAIR PHARMACOL, DEPT EXPTL BIOL, I-09100 CAGLIARI, ITALY

来源：

NEUROPSYCHOBIOLOGY | 1990年 / 23卷 / 03期

关键词：

ANTIDEPRESSANTS; 36CL-UPTAKE; FORCED SWIMMING TEST; PICROTOXIN; PENTYLENETETRAZOL;

D O I：

10.1159/000119442

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated Cl-36-uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A, B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action.

引用

页码：147 / 152

页数：6

共 43 条

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BARBACCIA ML, 1986, J PHARMACOL EXP THER, V236, P307

[2]

BARTHOLINI G, 1986, GABA MOOD DISORDERS, P105

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