NEURON SPECIFIC ENOLASE (NSE) IN SMALL-CELL LUNG-CANCER - A TUMOR-MARKER OF PROGNOSTIC-SIGNIFICANCE

被引：55

作者：

HARDING, M

MCALLISTER, J

HULKS, G

VERNON, D

MONIE, R

PAUL, J

KAYE, SB

机构：

[1] UNIV GLASGOW, DEPT MED ONCOL, GLASGOW G12 8QQ, SCOTLAND

[2] UNIV GLASGOW, DEPT BIOCHEM, GLASGOW G12 8QQ, SCOTLAND

[3] WESTERN INFIRM & ASSOCIATED HOSP, DEPT RESP MED, GLASGOW G11 6NT, SCOTLAND

[4] VICTORIA INFIRM, GLASGOW G42 9TY, SCOTLAND

[5] SO GEN HOSP, GLASGOW G51 4TF, SCOTLAND

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 61卷 / 04期

关键词：

D O I：

10.1038/bjc.1990.134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pretreatment serum levels of neurone specific enolase (NSE) were measured in patients with small cell lung cancer (SCLC). Median values were significantly higher in patients with extensive compared with limited stage disease (48 ng ml-1 v. 17 ng ml-1: P<0. 001). Serial NSE levels paralleled the clinical response to treatment. In 37 patients with limited SCLC, receiving identical chemotherapy, the pretreatment NSE level was of prognostic significance: with an approximate reduction in median survival of 10% for each 5 ng ml1־incremental rise in NSE (P = 0. 004). © Macmillan Press Ltd., 1990.

引用

页码：605 / 607

页数：3

共 15 条

[1] SERUM NEURON-SPECIFIC ENOLASE - A MARKER FOR DISEASE EXTENT AND RESPONSE TO THERAPY FOR SMALL-CELL LUNG-CANCER [J].