BIOLOGICAL-ACTIVITIES OF CYSTIC-FIBROSIS SERUM .3. CF SERUM INDUCED UPTAKE OF CA-45++ BY RABBIT TRACHEAL EXPLANTS

被引：9

作者：

BOGART, BI ^{[1
]}

CONOD, EJ ^{[1
]}

GAERLAN, PF ^{[1
]}

DENNING, CR ^{[1
]}

CONOVER, J ^{[1
]}

机构：

[1] ST VINCENTS HOSP & MED CTR,NEW YORK,NY 10016

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91135-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cystic Fibrosis (CF) serum and its isolated component IgG fraction produce an increased uptake of 45Ca++ in rabbit tracheal explants when compared to control serum and its isolated IgG fraction. Heterozygote serum also produced an increased uptake of 45Ca++ but not to the same extent as CF serum. The calcium channel blocker D600 inhibited the CF serum induced uptake of 45Ca++ indicating that CF serum may be acting on the plasma membrane to produce changes in calcium permeability in rabbit tracheal explants. © 1979.

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页码：1398 / 1404

页数：7

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