THE TRH-LIKE PEPTIDE PGLU-GLU-PRONH2 IS PRESENT IN THE PORCINE PITUITARY BUT NOT IN REPRODUCTIVE TISSUES

被引:22
作者
ASHWORTH, RJ [1 ]
VISSER, TJ [1 ]
COCKLE, SM [1 ]
机构
[1] ERASMUS UNIV, DEPT MED, 3000 DR ROTTERDAM, NETHERLANDS
基金
英国惠康基金;
关键词
D O I
10.1016/0006-291X(91)92116-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The peptide pGlu-Glu-ProNH2, which differs from thyrotrophin-releasing hormone (TRH) by only one amino acid, was initially detected and characterised in the rabbit prostate complex and more recently in human semen and rat pituitary. A previous study reported that TRH and a homologous peptide were present in a range of porcine tissues and it was of interest to further characterise these peptides. In this study, high levels of TRH-immunoreactivity have been demonstrated in the porcine pituitary, the majority of which was authentic TRH; although 9% was found to be chromatographically identical to pGlu-Glu-ProNH2. In contrast, TRH-immunoreactivity was not detected in follicular fluid, ovary or prostate. The unexpected finding that pGlu-Glu-ProNH2 is present in the porcine pituitary but absent from regions of the reproductive tract may be of biological significance. © 1991.
引用
收藏
页码:1557 / 1563
页数:7
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