IS NAN-190 AN EFFECTIVE ANTAGONIST OF THE HYPOTHERMIA AND HYPERGLYCEMIA INDUCED BY THE 5-HT1A RECEPTOR AGONIST, 8-OH-DPAT

被引：25

作者：

WOZNIAK, KM

DURCAN, MJ

LINNOILA, M

机构：

[1] Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, MD 20892, Bldg. 10/3B19

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 193卷 / 02期

关键词：

NAN-190; 8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); BODY TEMPERATURE; BLOOD GLUCOSE; 5-HT1A RECEPTORS; (MOUSE);

D O I：

10.1016/0014-2999(91)90044-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The putative 5-HT1A receptor antagonist properties of 1-(2-methoxyphenyl)-4-[4-(2-phtalimmido)butyl] piperazine (NAN-190) were studied in mice. The responses studied were hypothermia- and hyperglycemia-induced by the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). NAN-190 (0.3-3 mg/kg) did not antagonize either response, but rather appeared to be additive with the effect produced by 8-OH-DPAT (0.25 mg/kg) alone, at least with respect to temperature. NAN-190, given alone in similar doses, caused hypothermia and hyperglycemia. These results suggest that NAN-190 has similar properties to 8-OH-DPAT with regard to temperature and glucose effects. Therefore, it does not appear to be a effective antagonist for all 5-HT1A-mediated responses.

引用

页码：253 / 256

页数：4

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