THE YEAST PUTATIVE TRANSCRIPTIONAL REPRESSOR RGM1 IS A PROLINE-RICH ZINC FINGER PROTEIN

被引：24

作者：

ESTRUCH, F

机构：

[1] Departament de Bioquímica i Biologia Molecular, Universitat de Valéncia

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 18期

关键词：

D O I：

10.1093/nar/19.18.4873

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonine content, suggesting that RGM1 and Egr proteins could have functional similarities.

引用

页码：4873 / 4877

页数：5

共 36 条

[1] A EUKARYOTIC TRANSCRIPTIONAL ACTIVATOR BEARING THE DNA SPECIFICITY OF A PROKARYOTIC REPRESSOR
BRENT, R
PTASHNE, M
[J]. CELL, 1985, 43 (03) : 729 - 736
[2] Broach J. R., 1983, EXPT MANIPULATION GE, P83
[3] ACE2, AN ACTIVATOR OF YEAST METALLOTHIONEIN EXPRESSION WHICH IS HOMOLOGOUS TO SW15
BUTLER, G
THIELE, DJ
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) : 476 - 485
[4] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS
CALL, KM
GLASER, T
ITO, CY
BUCKLER, AJ
PELLETIER, J
HABER, DA
ROSE, EA
KRAL, A
YEGER, H
LEWIS, WH
JONES, C
HOUSMAN, DE
[J]. CELL, 1990, 60 (03) : 509 - 520
[5] 2 DIFFERENTIALLY REGULATED MESSENGER-RNAS WITH DIFFERENT 5' ENDS ENCODE SECRETED AND INTRACELLULAR FORMS OF YEAST INVERTASE
CARLSON, M
BOTSTEIN, D
[J]. CELL, 1982, 28 (01) : 145 - 154
[6] A GENE ENCODING A PROTEIN WITH ZINC FINGERS IS ACTIVATED DURING G0/G1 TRANSITION IN CULTURED-CELLS
CHAVRIER, P
ZERIAL, M
LEMAIRE, P
ALMENDRAL, J
BRAVO, R
CHARNAY, P
[J]. EMBO JOURNAL, 1988, 7 (01) : 29 - 35
[7] THE SEGMENT-SPECIFIC GENE KROX-20 ENCODES A TRANSCRIPTION FACTOR WITH BINDING-SITES IN THE PROMOTER REGION OF THE HOX-1.4 GENE
CHAVRIER, P
VESQUE, C
GALLIOT, B
VIGNERON, M
DOLLE, P
DUBOULE, D
CHARNAY, P
[J]. EMBO JOURNAL, 1990, 9 (04) : 1209 - 1218
[8] A GENE ACTIVATED IN MOUSE 3T3-CELLS BY SERUM GROWTH-FACTORS ENCODES A PROTEIN WITH ZINC FINGER SEQUENCES
CHRISTY, BA
LAU, LF
NATHANS, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) : 7857 - 7861
[9] ANALYSIS OF SP1 INVIVO REVEALS MULTIPLE TRANSCRIPTIONAL DOMAINS, INCLUDING A NOVEL GLUTAMINE-RICH ACTIVATION MOTIF
COUREY, AJ
TJIAN, R
[J]. CELL, 1988, 55 (05) : 887 - 898
[10] DIAKUN GP, 1986, NATURE, V324, P689

← 1 2 3 4 →