COMPARATIVE EFFECTS OF CYCLOSPORINE-A AND FK-506 ON ENDOTHELIN SECRETION BY A CULTURED RENAL-CELL LINE, LLC-PK1

被引：20

作者：

NAKAHAMA, H

FUKUNAGA, M

KAKIHARA, M

HORIO, M

FUJIWARA, Y

FUKUHARA, Y

UEDA, N

ORITA, Y

KAMADA, T

机构：

[1] First Department of Medicine, Osaka University Medical School, Osaka

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷

关键词：

CYCLOSPORINE-A; FK-506; LLC-PK1; CELLS; ENDOTHELIN;

D O I：

10.1097/00005344-199100177-00048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclosporine A (CSA) stimulated endothelin secretion by a cultured renal epithelial cell line, LLC-PK1. A less nephrotoxic immunosuppressant (FK-506) did not affect endothelin secretion. Putative endothelin converting enzyme inhibitors or specific receptor antagonists may therefore prevent CSA nephrotoxicity.

引用

页码：S172 / S173

页数：2

共 7 条

[1]

BAXTER CR, 1984, RES COMMUN CHEM PATH, V43, P417

[2] EVIDENCE THAT RENAL PROSTAGLANDIN AND THROMBOXANE PRODUCTION IS STIMULATED IN CHRONIC CYCLOSPORINE NEPHROTOXICITY [J].