FATE OF A SINGLE DOSE OF THE C-14-LABELED MYCOTOXIN, FUMONISIN-B1, IN RATS

The fate of the mycotoxin fumonisin B1 (FB1) dosed to rats by i.p. injection and by gavage was traced using C-14-labelled FB1. Twenty-four hours after i.p. injection, 66% of the radioactivity was recovered in faeces, 32% in urine, 1% in liver and trace amounts (< 1%) in kidney and red blood cells. When dosed by gavage, all (101%) radioactivity was recovered in faeces and trace amounts were found in urine, liver, kidney and red blood cells. The bulk of the radioactivity recovered was unmetabolized FB1.