SYNTHESIS OF THYROTROPIN-RELEASING HORMONE ENANTIOMER AND SOME DIASTEREOISOMERS AND IN-VITRO STUDIES OF THEIR BIOLOGICAL-ACTIVITY

被引：23

作者：

FLOURET, G

MORGAN, R

GENDRICH, R

WILBER, J

SEIBEL, M

机构：

[1] ABBOT LABS,RES DIV,ORG CHEM DEPT,N CHICAGO,IL 60064

[2] NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL,CHICAGO,IL 60611

[3] ABBOTT LABS,RES DIV,BIOCHEM DEPT,N CHICAGO,IL 60064

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1973年 / 16卷 / 10期

关键词：

D O I：

10.1021/jm00268a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1137 / 1140

页数：4

共 16 条

[1]

BEYERMAN HC, 1965, RECL TRAV CHIM PAY-B, V84, P213

[2]

BEYERMAN HC, 1971, RECL TRAV CHIM PAY-B, V90, P791

[3] ACTIVITY-STRUCTURE RELATIONSHIPS OF THYROTROPIN RELEASING HORMONE [J].

BOWERS, CY ;

SIEVERTSSON, H ;

ENZMANN, F ;

FOLKERS, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 40 (03) :683-+

[4]

BURGUS R, 1969, CR ACAD SCI D NAT, V269, P226

[5] SYNTHESIS OF C-14-LABELED THYROTROPIN RELEASING HORMONE (PYROGLUTAMYLHISTIDYL -C-14(U)-PROLINEAMIDE) [J].

FLOURET, G ;

ALTER, A ;

GENDRICH, R .

JOURNAL OF LABELLED COMPOUNDS, 1972, 8 (01) :53-&

[6] SYNTHESIS OF PYROGLUTAMYLHISTIDYLPROLINEAMIDE BY CLASSICAL AND SOLID PHASE METHODS [J].

FLOURET, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (05) :843-&

[7]

GREENSTEIN JP, 1961, CHEMISTRY AMINO ACID, V3

[8] SYNTHETIC POLYPEPTIDES .2. POLYGLUTAMIC ACID [J].

HANBY, WE ;

WALEY, SG ;

WATSON, J .

JOURNAL OF THE CHEMICAL SOCIETY, 1950, (NOV) :3239-3249

[9] SYNTHESIS OF A PENTAPEPTIDE BY MERRIFIELD METHOD [J].

LOFFET, A .

EXPERIENTIA, 1967, 23 (05) :406-&

[10]

MANNING JM, 1968, J BIOL CHEM, V243, P5591

← 1 2 →