RELAPSING AND REMITTING HUMAN-IMMUNODEFICIENCY-VIRUS ASSOCIATED LEUKOENCEPHALOMYELOPATHY

被引：54

作者：

BERGER, JR

TORNATORE, C

MAJOR, EO

BRUCE, J

SHAPSHAK, P

YOSHIOKA, M

HOUFF, S

SHEREMATA, W

HORTON, GF

LANDY, H

机构：

[1] UNIV MIAMI,SCH MED,DEPT NEUROL,1501 NW 9TH AVE,MIAMI,FL 33151

[2] ST VINCENTS MED CTR,JACKSONVILLE,FL

[3] NINCDS,NEUROVIROL SECT,BETHESDA,MD 20892

[4] UNIV MIAMI,SCH MED,DEPT INTERNAL MED,MIAMI,FL 33152

[5] GEORGETOWN UNIV,SCH MED,DEPT NEUROL,WASHINGTON,DC 20057

[6] UNIV MIAMI,SCH MED,DEPT PATHOL,MIAMI,FL 33152

[7] UNIV MIAMI,SCH MED,DEPT NEUROSURG,MIAMI,FL 33152

[8] UNIV MIAMI,SCH MED,DEPT PSYCHIAT,MIAMI,FL 33152

来源：

ANNALS OF NEUROLOGY | 1992年 / 31卷 / 01期

关键词：

D O I：

10.1002/ana.410310107

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.

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页码：34 / 38

页数：5

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