STRETCH-ACTIVATION OF RAT CARDIAC MYOCYTES

被引：43

作者：

CRAELIUS, W

机构：

来源：

EXPERIMENTAL PHYSIOLOGY | 1993年 / 78卷 / 03期

关键词：

D O I：

10.1113/expphysiol.1993.sp003695

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mechanically activated ion channels (MACs) in rat ventricular myocytes were activated by stretching membrane patches attached to microelectrodes. Charge injection from MACs, consisting mainly of inward K+, was sometimes of sufficient magnitude (0-2 pC) during brief (50 ms) periods, to trigger action currents. Action currents were shown to be extracellular records of action potentials. These results demonstrate the activation of myocytes by injection of approximately 4 pA from a few MACs in a membrane patch.

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页码：411 / 423

页数：13

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