HYALURONAN REDUCES FLUID ESCAPE RATE FROM RABBIT KNEE JOINTS DISPARATELY FROM ITS EFFECT ON FLUIDITY

被引：19

作者：

MCDONALD, JN ^{[1
]}

LEVICK, JR ^{[1
]}

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT PHYSIOL,LONDON SW17 0RE,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1994年 / 79卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1113/expphysiol.1994.sp003736

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effect of hyaluronan, the major viscous component of synovial fluid, on trans-synovial flow was measured in rabbit knees. Hyaluronan reduced fluid escape rate by up to 45%. This was much less than the reduction in intra-articular fluidity (1/viscosity). Electron micrographs supported the view that hyaluronan might be partially reflected by synovium, creating a molecular filtercake at the surface.

引用

页码：103 / 106

页数：4

共 12 条

[1]

Balazs EA., 1985, J EQUINE VET SCI, V5, P217, DOI [DOI 10.1016/S0737, 10.1016/S0737-0806(85)80102-7, DOI 10.1016/S0737-0806(85)80102-7]

[2] IONIC POLYSACCHARIDES .3. DILUTE SOLUTION PROPERTIES OF HYALURONIC ACID FRACTIONS [J].

CLELAND, RL ;

WANG, JL .

BIOPOLYMERS, 1970, 9 (07) :799-&

[3]

de Gennes P.-G, 1979, SCALING CONCEPTS POL

[4]

FLORY PJ, 1971, PRINCIPLES POLYM CHE

[5]

HENDERSON B, 1987, SYNOVIAL LINING

[6] SYNOVIAL-FLUID - ITS MASS, MACROMOLECULAR CONTENT AND PRESSURE IN MAJOR LIMB JOINTS OF THE RABBIT [J].

KNOX, P ;

LEVICK, JR ;

MCDONALD, JN .

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1988, 73 (01) :33-45

[7] EFFECTS OF ALBUMIN, DEXTRAN, AND HYALURONIDASE ON PULMONARY INTERSTITIAL CONDUCTIVITY [J].

LAIFOOK, SJ ;

ROCHESTER, NL ;

BROWN, LV .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (02) :606-613

[8]

Levick J., 1983, STUDIES JOINT DISEAS, P153

[9] ULTRASTRUCTURE OF TRANSPORT PATHWAYS IN STRESSED SYNOVIUM OF THE KNEE IN ANESTHETIZED RABBITS [J].

LEVICK, JR ;

MCDONALD, JN .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 419 :493-508

[10]

LEVICK JR, 1993, IN PRESS MICROVASCUL

← 1 2 →