UPTAKE OF [NIPECOTIC-C-14 ACID INTO RAT DORSAL ROOT-GANGLIA

被引：19

作者：

MINCHIN, MCW ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,DEPT PHARMACOL,CANBERRA 2600,ACT,AUSTRALIA

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb11093.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— [14C]Nipecotic acid was accumulated in isolated desheathed rat dorsal root ganglia by a saturable process with Km= 48.8 μm and Vmax= 2.2 nmol/g/min. The concentration of l‐2.4‐diamino‐butyric acid required to inhibit the uptake of nipecotic acid by 50% was three times the concentration of β‐alanine required to do the same. Light microscopic autoradiography indicated that the sites of uptake of [14C]nipecotic acid were principally confined to satellite glial cells. It is concluded that nipecotic acid is transported by the GABA uptake system in glia but that it has less affinity for this system than GABA. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1519 / &

共 10 条

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