PHARMACOKINETICS OF THE HYPNOTIC BENZODIAZEPINE, TEMAZEPAM

Our results confirm the findings of Fuccella et al. (1977) for the pharmacokinetics of temazepam administered during the daytime in the form of a soft gelatin liquid-filled capsule formulation. Thus, temazepam (Normison) was absorbed and eliminated rapidly after oral administration. Both the rapid rate of absorption and short elimination half-life are properties required of an hypnotic and correlate with the rapid sleep induction and absence of residual drug effects on waking found with the therapeutic use of temazepam. With a mean half-life of 8.3 h minimal accumulation on repeated daily use of the drug would be expected.