PERIODIC BIOSYNTHESIS OF THE HUMAN M-PHASE PROMOTING FACTOR CATALYTIC SUBUNIT P34 DURING THE CELL-CYCLE

被引：102

作者：

MCGOWAN, CH ^{[1
]}

RUSSELL, P ^{[1
]}

REED, SI ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES FDN,RES INST,DEPT MOLEC BIOL,10666 N TORREY PINES RD,LA JOLLA,CA 92037

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 07期

关键词：

D O I：

10.1128/MCB.10.7.3847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The product of the CDC2Hs gene is the protein kinase subunit of the M-phase promoting factor, which is required for entry into mitosis. The activity of this kinase is regulated in a cell cycle-dependent manner by reversible phosphorylation and through association with other proteins. We report here that in HeLa cells, the abudance of the CDC2Hs mRNA and the rate of synthesis of the encoded protein, p34, vary in a cell cycle-dependent manner.

引用

页码：3847 / 3851

页数：5

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