IGG SUBCLASS DISTRIBUTION OF ANTI-HBS ANTIBODIES FOLLOWING VACCINATION WITH CDNA HBSAG

被引：18

作者：

BORZI, RM

DALMONTE, P

HONORATI, MC

FACCHINI, A

机构：

[1] IST RIC CODIVILLA PUTTI,IMMUNOL & GENET LAB,VIA BARBIANO 1-10,I-40136 BOLOGNA,ITALY

[2] UNIV BOLOGNA,IST ORTOPED RIZZOLI,IMMUNOL & GENET LAB,I-40126 BOLOGNA,ITALY

[3] UNIV BOLOGNA,IST CLIN MED & GASTROENTEROL,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1992年 / 146卷 / 01期

关键词：

IGG SUBCLASS; HBSAG; VACCINATION;

D O I：

10.1016/0022-1759(92)90043-S

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum samples were obtained during follow-up of nine young adults vaccinated over 1 year with cDNA hepatitis B antigen. The absolute amounts of anti-HBs IgG subclass antibodies present in the sera were determined by comparing the optical densities (OD) obtained using an antigen-specific ELISA with those obtained by serial dilutions of known amounts of human IgG1-4. The calibration curves for each IgG subclass were corrected for the corresponding coating efficiency. Our data suggest that HBs antibody responses of vaccinated subjects occur in all IgG subclasses but IgG1 and IgG2 are the major subclasses involved.

引用

页码：17 / 23

页数：7

共 10 条

[1] THE ADSORPTIVE CHARACTERISTICS OF PROTEINS FOR POLYSTYRENE AND THEIR SIGNIFICANCE IN SOLID-PHASE IMMUNOASSAYS [J].