PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) EXPRESSION IN FORMALIN-FIXED TISSUE OF NON-SMALL-CELL LUNG-CARCINOMA

被引:61
作者
THEUNISSEN, PHMH [1 ]
LEERS, MPG [1 ]
BOLLEN, ECM [1 ]
机构
[1] DE WEVER HOSP, DEPT SURG, 6401 CX HEERLEN, NETHERLANDS
关键词
NON-SMALL-CELL LUNG CARCINOMA; PCNA LABELING INDEX; MITOTIC INDEX;
D O I
10.1111/j.1365-2559.1992.tb00964.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
An immunohistochemical study of non-small cell lung carcinoma using PC1O, a monoclonal antibody against PCNA, was performed on tissues routinely processed with formalin fixation and paraffin embedding. The PCNA labelling index and mitotic index were determined from sections of these tissues. Tumours showed a high mean PCNA labelling index of 53.3%. The mean mitotic index was 10.3/1000 cells. Inter-examiner agreement of mitotic counting was good. A linear correlation between the PCNA labelling index and mitotic index was demonstrated (r = 0.71, P < 0.00001). It is concluded that immunohistochemical nuclear labelling with anti-PCNA on routinely processed tissue is a simple technique for the assessment of proliferation in non-small cell lung carcinoma.
引用
收藏
页码:251 / 255
页数:5
相关论文
共 17 条
[1]   MITOSIS COUNTING IN TUMORS [J].
BAAK, JPA .
HUMAN PATHOLOGY, 1990, 21 (07) :683-685
[2]   CORRELATION OF PROLIFERATIVE ACTIVITY IN BREAST-TISSUE USING PCNA CYCLIN [J].
BATTERSBY, S ;
ANDERSON, TJ .
HUMAN PATHOLOGY, 1990, 21 (07) :781-781
[3]   CYCLIN PCNA IS THE AUXILIARY PROTEIN OF DNA POLYMERASE-DELTA [J].
BRAVO, R ;
FRANK, R ;
BLUNDELL, PA ;
MACDONALDBRAVO, H .
NATURE, 1987, 326 (6112) :515-517
[4]   EXISTENCE OF 2 POPULATIONS OF CYCLIN PROLIFERATING CELL NUCLEAR ANTIGEN DURING THE CELL-CYCLE - ASSOCIATION WITH DNA-REPLICATION SITES [J].
BRAVO, R ;
MACDONALDBRAVO, H .
JOURNAL OF CELL BIOLOGY, 1987, 105 (04) :1549-1554
[6]   PCNA/CYCLIN EXPRESSION AND BRDU UPTAKE DEFINE DIFFERENT SUBPOPULATIONS IN DIFFERENT CELL-LINES [J].
COLTRERA, MD ;
GOWN, AM .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1991, 39 (01) :23-30
[7]   CHANGES IN MITOTIC RATE AND CELL-CYCLE FRACTIONS CAUSED BY DELAYED FIXATION [J].
DONHUIJSEN, K ;
SCHMIDT, U ;
HIRCHE, H ;
VANBEUNINGEN, D ;
BUDACH, V .
HUMAN PATHOLOGY, 1990, 21 (07) :709-714
[8]  
GARCIA RL, 1989, AM J PATHOL, V134, P733
[9]  
GREENBERG SD, 1987, PATHOL ANNU, V22, P387
[10]  
HAAS M, 1991, J MANIP PHYSIOL THER, V14, P119