SLEEP SHIFT DISSOCIATES THE NOCTURNAL PEAKS OF PARATHYROID-HORMONE (1-84), NEPHROGENOUS CYCLIC ADENOSINE-MONOPHOSPHATE, AND PROLACTIN IN NORMAL MEN

被引:20
作者
LOGUE, FC
FRASER, WD
OREILLY, DS
CHRISTIE, J
CAMERON, DA
WALLACE, DC
BEASTALL, GH
机构
关键词
D O I
10.1210/jc.75.1.25
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The secretion of PTH(1-84) and PRL over a 24-h period in normal subjects has been shown to be highly correlated, with changes in PRL occurring approximately 2 h after those in PTH(1-84). It has been postulated that there may be neuroendocrine control common to PTH(1-84) and PRL. As the secretion of PRL is known to be strongly influenced by sleep we investigated the effect of a 7-h acute sleep shift on the nocturnal secretion of PTH(1-84), PRL, and nephrogenous cAMP, a marker of PTH(1-84) bioactivity. Six normal male subjects were studied on two occasions (study A sleep, 0100-0800 h; study B, 0800-1400 h) with samples withdrawn at 30-min intervals. Sleep shift produced the expected shift in PRL secretion to new time of sleep. The overall timing of the PTH(I-84) nocturnal peak (0200-0600 h) was not altered by sleep shift. However, the start of the rise in PTH(1-84) (0200-0300 h) was blunted (P < 0.05), and the peak of nephrogenous cAMP, coincident with the nocturnal rise in PTH(1-84) in study A, was markedly attenuated (P < 0.01). Thus whereas the results of this study argue against a direct neuroendocrine link between PTH(1-84) and PRL, it is postulated that sleep shift disrupts a high degree of temporal organization which, under normal conditions, may allow concerted metabolic effects between PTH(1-84) and other hormones over a 24-h period.
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页码:25 / 29
页数:5
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