LOCALIZED PROTON MR SPECTROSCOPY OF THE BRAIN IN CHILDREN

被引：49

作者：

TZIKA, AA

VIGNERON, DB

BALL, WS

DUNN, RS

KIRKS, DR

机构：

[1] Department of Radiology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio

[2] Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio

[3] Magnetic Resonance Science Center, University of California, San Francisco

[4] Department of Radiology, Children's Hospital and Harvard Medical School, Boston, Massachusetts

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 05期

关键词：

BRAIN; DISEASES; INJURIES; ISCHEMIA; MR; BRAIN NEOPLASMS; IN INFANTS AND CHILDREN; MAGNETIC RESONANCE (MR); SPECTROSCOPY;

D O I：

10.1002/jmri.1880030506

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Small-voxel (3.0-8.0 cm3), magnetic resonance (MR) imaging-guided proton MR spectroscopy was performed in 54 patients (aged 6 days to 19 years) with intracranial masses (n = 16), neurodegenerative disorders (n = 34), and other neurologic diseases (n = 4) and in 23 age-matched control subjects without brain disease. A combined short TE (18 msec) stimulated-echo acquisition mode (STEAM) and long TE (135 and/or 270 msec) spin-echo point-resolved spatially localized spectroscopy (PRESS) protocol, using designed radio-frequency pulses, was performed at 1.5 T. STEAM spectra revealed short T2 and/or strongly coupled metabolites; prominent resonances were obtained from N-acetyl aspartate (NAA), choline-containing compounds (Cho), and total creatine (tCr). Lactate was well resolved with the long TE PRESS sequence. Intracranial tumors were readily differentiated from cerebrospinal fluid (CSF) collections. All tumors showed low NAA, high Cho, and reduced tCr levels. Neurodegenerative disorders showed low or absent NAA levels and enhanced mobile lipid, glutamate and glutamine, and inositol levels, consistent with neuronal loss, gliosis, demyelination, and amino acid neurotoxicity. Preliminary experience indicates that proton MR spectroscopy can contribute in the evaluation of central nervous system abnormalities of infants and children.

引用

页码：719 / 729

页数：11

共 46 条

[1]

Radda GK, Rajagopalan B, Taylor DJ, Biochemistry in vivo: an appraisal of clinical magnetic resonance spectroscopy, Magn Reson Q, 5, pp. 122-151, (1989)

[2]

Weiner MW, The promise of magnetic resonance spectroscopy for medical diagnosis, Invest Radiol, 23, pp. 253-261, (1988)

[3]

Bottomley PA, Human in vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe?, Radiology, 170, pp. 1-15, (1989)

[4]

Aue WP, Localization methods for in vivo nuclear magnetic resonance spectroscopy, Rev Magn Reson Med, 1, pp. 21-72, (1986)

[5]

Moonen CTW, Von Kienlin M, Van Ziil PCM, Et al., Comparison of single‐shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy, NMR Biomed, 2, pp. 201-208, (1989)

[6]

Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Sauter R. Localized high‐resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo, Magn Reson Med, 9, pp. 79-93, (1989)

[7]

Rothman DL, Hanstock CC, Petroff AC, Novotny EJ, Prichard JW, Shulman RG, Localized <sup>1</sup>H NMR spectra of glutamate in the human brain, Magn Reson Med, 25, pp. 94-106, (1992)

[8]

Kreis R, Ross BD, Farrow NA, Ackerman Z, Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H‐1 MR spectroscopy, Radiology, 182, pp. 19-27, (1992)

[9]

Bruhn H, Kruse B, Korenke GC, Et al., Proton NMR spectroscopy of cerebral metabolic alterations in infantile peroxisomal disorders, J Comput Assist Tomogr, 16, pp. 335-344, (1992)

[10]

Van der Knaap MS, Van der Grond J, Van Rijen PC, Faber JA, Valk J, Willemse K, Age‐dependent changes in localized proton and phosphorus MR spectroscopy of the brain, Radiology, 176, pp. 509-515, (1990)

← 1 2 3 4 5 →