LYMPHOMA VERSUS PSEUDOLYMPHOMA OF THE SKIN - GENE REARRANGEMENT STUDY OF 21 CASES WITH CLINICOPATHOLOGICAL CORRELATION

被引:45
作者
LANDA, NG [1 ]
ZELICKSON, BD [1 ]
PETERS, MS [1 ]
MULLER, SA [1 ]
PITTELKOW, MR [1 ]
机构
[1] MAYO CLIN & MAYO FDN, DEPT DERMATOL, 200 1ST ST SW, ROCHESTER, MN 55905 USA
关键词
D O I
10.1016/0190-9622(93)70272-U
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background- Diagnosis of cutaneous lymphoma in the absence of systemic lymphoma may be difficult. Reactive lymphoid lesions can mimic lymphoma clinically and histologically and have been designated pseudolymphomas. Objective: Our purpose was to analyze lymphoid gene rearrangements in cutaneous lymphoproliferative lesions and to correlate these findings with the histologic, immunophenotypic, and clinical profile. Methods: We examined 21 cases of lymphoproliferative lesions that developed in skin and performed molecular rearrangement analysis of T-cell receptor and immunoglobulin genes. We examined identical tissues by histologic and immunophenotypic criteria and conducted follow-up clinical evaluation of all patients. Results. Clonal rearrangements of immunoglobulin (seven cases) or T-cell receptor (two cases) gene were detected in 9 of 21 patients. No specific histologic or immunophenotypic feature was consistently associated with a clonal lymphoid gene rearrangement. Systemic lymphoma developed in one patient in whom a clonal rearrangement within the immunoglobulin gene was identified. Conclusion: Gene rearrangement analysis may be helpful in differentiating primary cutaneous lymphoma from pseudolymphoma. The chronic clinical course of patients with clonal lymphoid gene rearrangements supports a lack of correlation between clonality and biologic aggressiveness.
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收藏
页码:945 / 953
页数:9
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