DECREASED PROSTACYCLIN PRODUCTION BY LIVER NONPARENCHYMAL CELLS PRECEDES LIVER-INJURY IN EXPERIMENTAL ALCOHOLIC LIVER-DISEASE

被引：21

作者：

NANJI, AA ^{[1
]}

KHWAJA, S ^{[1
]}

SADRZADEH, SMH ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02215 USA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 07期

关键词：

D O I：

10.1016/0024-3205(94)00404-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We used the intragastric feeding rat model for alcoholic liver disease to investigate the relationship between prostacyclin and liver injury. Rats were fed the following diets for periods ranging from 1 to 8 weeks: corn oil plus ethanol (CO+E), corn oil plus dextrose (CO+D), saturated fat plus ethanol (SF+E) and saturated fat plus dextrose (SF+D). Prostacyclin production (assessed by 6-ketoprostaglandin F-1 alpha) by liver non-parenchymal cells decreased steadily over the g week period in animals fed CO+E (liver injury present) whereas in animals fed SFt-E (no liver injury) there was no change in prostacyclin production. Plasma levels of 6-ketoprostaglandin F-1 alpha were also significantly lower in the CO+E group compared to the other groups studied. We propose that decreased prostacyclin production by liver non-parenchymal cells may contribute to the hepatotoxic effect of ethanol.

引用

页码：455 / 461

页数：7

共 21 条

[1] THROMBOXANE AND PROSTACYCLIN DIFFERENTIALLY REGULATE MURINE EXTRACELLULAR-MATRIX GENE-EXPRESSION [J].