STEROIDAL SAPONINS FROM THE BULBS OF LILIUM-LONGIFLORUM AND THEIR ANTITUMOR-PROMOTER ACTIVITY

被引：40

作者：

MIMAKI, Y

NAKAMURA, O

SASHIDA, Y

SATOMI, Y

NISHINO, A

NISHINO, H

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIGYO KU,KYOTO 602,JAPAN

[2] NATL CANC CTR,RES INST,DIV CANC PREVENT,CHUO KU,TOKYO 104,JAPAN

来源：

PHYTOCHEMISTRY | 1994年 / 37卷 / 01期

关键词：

LILIUM LONGIFLORUM; LILIACEAE; BULBS; STEROIDAL SAPONINS; SPIROSTANOL SAPONINS; FUROSTANOL SAPONINS; PHOSPHOLIPID METABOLISM; HELA CELLS; ANTITUMOR-PROMOTER ACTIVITY;

D O I：

10.1016/0031-9422(94)85030-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new spirostanol saponins and two new furostanol saponins were isolated from the fresh bulbs of Lilium longiflorum together with several known saponins. The structures of new compounds were determined to be (25S)-spirost- 5-ene-3 beta,27-diol 3-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-arabinopyranosyl-(1-->3)]-beta-D-glucopyranoside}, (25R)-27-O-[(S)-3-hydroxy-3-methylglutaryl]-spirost-5-ene-3 beta,27-diol 3-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-arabinopyranosyl-(1-->3)]-beta-D-glucopyranoside}, 22-O-methyl-26-O-beta-D-glucopyranosyl-(25R)-furost-5-ene-3 beta,22 xi,26-triol 3-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-arabinopyranosyl-(1-->3)]-beta-D-glucopyranoside} and 22-O-methyl-26-O-beta-D-glucopyranosyl-(25R)furost-5-ene-3 beta,22 xi,26-triol 3-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucopyranoside}. The isolated saponins and their derivatives were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated P-32-incorporation into phospholipids of HeLa cells as the primary screening test to find new antitumour-promoter compounds.

引用

页码：227 / 232

页数：6

共 16 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].